Protein Details: Neuronal acetylcholine receptor subunit alpha-10

Protein ID

ICDB_Pro_1503

Protein Name

Neuronal acetylcholine receptor subunit alpha-10

Gene Name

CHRNA10; NACHRA10

Organism

Homo sapiens (Human)

Length

450 amino acids

AlphaFoldDB

AF-Q9GZZ6-F1-model_v4.pdb

Function

After binding acetylcholine;the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

Sequence

MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Episodic Kinesigenic Dyskinesia 2 and Tobacco Addiction

Location

Expressed in the brain (at protein level)

DOI ID

10.1126/science.1112014; 10.1523/jneurosci.4723-08.2009

RefSeq

NP_660111.2